



With Yom Kippur's 25-hour fast approaching, an obesity medicine specialist lays out guidance for the millions on GLP-1 drugs like Ozempic and Wegovy who plan to observe it. The core advice: don't start a new drug or increase your dose within two weeks of the fast, stick to your weekly injection schedule even while fasting, and if you take a daily oral pill, decide in advance whether to take it before or after the fast since it typically requires water.
The stakes vary sharply by patient. Weight-loss-only users risk mostly stomach upset, while diabetic patients on insulin or sulfonylurea drugs face real risk of dangerous blood sugar swings and should consult their doctor before attempting to fast at all.
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